Switching defects

Switching defects

The blood clotting protein fibrinogen can inadvertently promote multiple sclerosis (MS) when it leaks from the blood into the brain. According to Adams et al. (page 571), it does so by activating microglia and sending these cells into phagocytic overdrive. Interrupting this interaction may yield a treatment for MS that doesn’t interfere with blood clotting. The neurological dysfunction seen in ...

Novel antibody switching defects in human patients.

Influence of dipolar defects on switching behavior in ferroelectrics

By including the contributions of dipolar defects in the time-dependent Ginzburg-Landau theory, we have simulated the domain switching process in ferroelectrics. The model incorporates elastic effects in the form of an anisotropic long-range interaction that is obtained by integrating out the strain fields, subject to the elastic compatibility constraint. The defects are simulated by considerin...

Correlation between switching to n-type conductivity and structural defects in highly Mg-doped InN

Multiple hematopoietic defects and delayed globin switching in Ikaros null mice.

We have previously reported the structure of a chromatin remodeling complex (PYR complex) with Ikaros as its DNA binding subunit that is specifically present in adult murine and human hematopoietic cells. We now show that homozygous Ikaros "knockout" (null) mice lack the PYR complex, demonstrating the requirement for Ikaros in the formation of the complex on DNA. Heterozygous Ikaros null mice h...